Esophageal Cancer in North West India: A Tertiary Care Center Experience of 5 Years

poor [5]. Despite various Abstract Background: Incidence of Esophageal cancer (EC) is increasing now a days and it has became a sixth leading cause of cancer related death in world. EC is associated with multiple risk factors. Despite various advances in the treatment of EC, it remains one of the least responsive tumors to cancer therapy, thereby overall prognosis remains poor. The current status of EC in North West India in relation to the demographics, diagnosis, staging, multimodality treatment, and the future perspectives are discussed. Methods and Materials: This is a retrospective analysis of medical records of the EC patients registered in the Department of Radiation Oncology SMS Medical and Attached Hospitals Jaipur from January 2015 to December 2019. Results: Out of 10,464 patients with various malignancies registered in SMS hospital for radiotherapy via Co-60 technique in the previous 5 years from 2015-2019; 449 were having EC. 40.25% patients were in 6 th decade and male to female ratio was 1.49:1. EC was most common in farmers (51.79%) and 76.16% patients were the resident of rural areas addicted with smoking (41.4%) and tobacco chewing (24.7%) habit. Dysphagia was the presenting feature in almost all the patients. Most common type and site of involvement were squamous type (75.72%) and middle third (45.43%) part of the esophagus respectively. 39.19% patients presented in stage III and 24.70% patients in stage IVA. The patients were planned with treatment according to their age, performance status, extent of disease and other co-morbidities. Conclusions: At our centre most of the patients landed up in advanced stage poverty, illiteracy, ignorance, late diagnosis. Majority of the EC patient were addicted with smoking and tobacco chewing habit, hence screening of high risk population and lifestyle modifications limiting the use of tobacco, may help in the early detection and can decrease the mortality related to EC. Careful selection of patients for radical treatment is very important for providing relatively longer disease free interval.


Introduction
and gastroesophageal junction cancers, which makes trimodal therapy the current standard of treatment of locally advanced EC. Despite these results, 2 European trials showed the possibility of upfront concurrent definitive CRT (dCRT) as a possible treatment of locally advanced ESCC [7,8]. Currently, this modality has been advocated for patients who decline or who are unsuitable for esophagectomy [9].
A better understanding of the etiology/risk factors, pattern of presentation of disease may suggest opportunity for its primary prevention. In view of this we have done retrospective study of biopsy proven esophageal cancer patients visiting Department of Radiation Oncology SMS Medical College and Hospitals Jaipur during a period of January 2015 to December 2019 in relation to the demographics, diagnosis, staging, treatment and the future perspectives for the better outcome of the disease.

Materials and Methods
This was a retrospective hospital record based study carried out in Department of Radiation Oncology SMS Medical College and Attached Hospitals Jaipur Rajasthan, India. For extracting data the radiotherapy files of the cancer patients registered in the hospital were collected from January 2015 to December 2019. A total of 10,464 patients with a variety of malignancies were registered in the last 5-year duration for RT with Cobalt-60 technique. Out of this, 449 were diagnosed to have EC. The parameters including age, gender, locality, occupation, addiction, staging and treatment patterns of the patients were studied. The site of the disease and the histology were also recorded.

Results
• A total of 449 patients were retrospectively analyzed with sociodemographic and clinical parameters at presentation to the hospital are summarized in Table 1 and Table 2 below.
• 40.25% patients presented in the 6 th decade of life with male preponderance and male to female ratio of 1.49:1 was there.
• 76.16% were the resident of rural area and 51.79% study population was farmer by occupation.
• Smoking (41.4%) being the most common risk factor for EC.

Clinical Characteristics of the patients
• All the patients presented at our center with the chief complaints of dysphagia for solids (100%) or for solids and liquid both (67%).
• Squamous cell carcinoma (75.72%) was the most common histology with middle third esophagus (45.43%) being the most common site of disease.
• Majority of the patients presented in stage III and IVA, 39.19% and 24.70% respectively and 14.47% of the patients were with metastasis at different site with liver metastasis being the most common at presentation.
• Patients with metastasis at presentation were planned with palliative radiotherapy (RT) for symptomatic relief for dysphagia, pain and bleeding.

Discussion
Esophageal cancer is an upper digestive tract cancer, mainly prevalent in developing and underdeveloped countries. In our study, 10.76% patients were of ≤40 years and majority of patients were in elderly age group with 40.25% presenting in age more than 60 years. It has been found that EC is rare in individuals younger than age 30 in both low and high incidence areas; EC cases in those ≤30 years of age in northern China, northeastern Iran, and the Surveillance, Epidemiology, and End Results (SEER) registries in the US account for 0.7, 1, and 0.5% of cases, respectively [10,11,12]. Another Indian study by Chitra et al., also reported similar age patterns with 5% cases below the age of 40 years with majority 62% cases of age group 41-60 year [13]. These studies were corroborating with the findings of this study. Though it is more common in males, the rate is increasing in females also. In the present study, we observed a male preponderance with a male to female ratio of 1 Western literature has reported alcohol and tobacco use to the major risk factor for SCC, accounting for 80-90% of the cases [18].In the present study also, the addiction of smoking was present in the majority (41.4%) of the patients. Alcohol and smoking abuse together was reported by 18.7% of the patients. Esophageal SCC risk is 4.2 times higher in current smokers in Europe compared with never-smokers, a meta-analysis showed [19].

The SMS Hospital Jaipur Experience
The 5 year experience (2015-2019) of the patients with respect to the sociodemographic and clinical parameters at presentation, to our institute are summarized in (Table 1) and (Table 2) respectively. All the patients were inoperable at presentation and majorities (39.19%) of them were in stage III. Of total 449 patients 181 were planned with NACRT (41.4-50.4Gy, with paclitaxel and carbobplatin) followed by surgery. Majority (45.21%) of patients were treated with definitive CTRT (50-50.4Gy). 65 patients presented with metastatic disease with liver metastasis done by Sankaranarayanan R et al. [14] found that the proportions of males was higher than females with ratio of 2:1. Another study done by Sehgal S et al. [15] also showed higher proportions of males than females with ratio of 2.1:1. Almost all of the patients in this study were presented with dysphagia as a chief presenting complaint and dysphagia was also the most common indication for upper GI endoscopy. Vishal Gupta et al find same type of presentation in his study [16].
In our study, about two-third of the EC patients were illiterate and half belonged to low socioeconomic status as per the modified BG Prasad scale. Sehgal et al. [15], also reported that the majority (63%) cases were illiterate and 59.5% from lower socioeconomic status. Thus, our data are in agreement with already published literature. The occupation that had highest relation with EC was found to be farming as farm based earning of livelihood is more prevalent in north-west India.
In our study, 22.4% patients had the malignancy of upper third of the esophagus; 45.43% patients had middle and 30.95% had carcinoma of the lower esophagus. In 1.11% of the patients, insufficient data were available to locate the exact site of the lesion. In another study by Giri et   (n=22, 4.89 %) being the most common and were treated symptomatically with palliative radiotherapy for the symptoms of pain, dysphagia, bleeding and others as indicated. Adequate caloric intake oral and/or enteral and IV hydration was maintained throughout chemoradiation and recovery.

Limitations
Lack of availability of the dietary habits of the patients.
In conclusion, the incidence of esophageal cancer in India is rising, but very limited data is available. Older age, male gender, lower socio economic status, smoking habit mostly contributes to development of EC. Cancer preventive measures and screening programs should be employed for the early detection of cancer. The most feasible method to reduce esophageal cancer burden is to identify and target etiological factors, improve socio-economic status, and screen the high-risk group of people as well as generating awareness regarding modification of lifestyle.