Analysis of Biochemical and Hematological Parameters During the First and Second Wave of SARS-CoV-2 Infection among North-East Indian Cancer Patients

Sawmik Das; Anupam Sarma; Biki Chandra Das; Dhruba Jyoti Sarma; Rashmisnata Barman; Mouchumee Bhattacharyya; Amal Chandra Kataki; Avdhesh Kumar Rai

doi:10.31557/apjcc.2022.7.4.637-642

Authors

Sawmik Das Department of Biochemistry, Dr B Borooah Cancer Institute, Gopinath Nagar, Guwahati 781016, Assam, India.
Anupam Sarma Department of Oncopathology, Dr B Borooah Cancer Institute, Gopinath Nagar, Guwahati 781016, Assam, India.
Biki Chandra Das DBT Centre for Molecular Biology and Cancer Research, Dr B Barooah Cancer Institute, Gopinath Nagar, Guwahati 781016, India.
Dhruba Jyoti Sarma DBT Centre for Molecular Biology and Cancer Research, Dr B Barooah Cancer Institute, Gopinath Nagar, Guwahati 781016
Rashmisnata Barman Department of Microbiology, Dr B Borooah Cancer Institute, Gopinath Nagar, Guwahati 781016, Assam, India.
Mouchumee Bhattacharyya Department of Radiation Oncology, Dr B Borooah Cancer Institute, Gopinath Nagar, Guwahati 781016, Assam, India.
Amal Chandra Kataki Department of Gynaecologic Oncology, Dr B Borooah Cancer Institute, Gopinath Nagar, Guwahati 781016, Assam, India.
Avdhesh Kumar Rai DBT Centre for Molecular Biology and Cancer Research, Dr B Barooah Cancer Institute, Gopinath Nagar, Guwahati 781016, India.

DOI:

https://doi.org/10.31557/apjcc.2022.7.4.637-642

Keywords:

SARS-CoV-2, Cancer, Biochemical parameters, hematological parameters

Abstract

Introduction: SARS-CoV-2 (COVID-19) affects respiratory airways as well as the kidneys, hearts etc. This study aims to demonstrate the impact of COVID-19 infection on biochemical and hematological parameters in cancer patients of North-East India.
Methods: The study includes biochemical parameters for 907 and hematological parameters for 1103 cancer patients who were tested for COVID-19 between 1^st June 2020 and 1^st June 2021. All the data were analyzed by the statistical software SPSS (ver20).
Results: AST (p = 0.023), GGT (p = 0.026) and Urea (p = 0.004) significantly increased in COVID-19 positive cancer patients compared to negative cancer patients. Eosinophils (p=0.01), eosinophils absolute (p=0.01), monocyte (p=0.04) and MCHC (p=0.01) were significantly decreased in COVID-19 positive cancer patients compared to negative. Various biochemical and haematological parameters analysed in our study were found to be altered between the COVID-19 positive and negative group but their association was not found to be statistically significant.
Conclusion: We conclude that in cancer patients of North-East India, significant alterations of biochemical and hematological parameters AST, GGT, Urea, Eosinophils, eosinophils absolute, monocyte and MCHC were found in COVID-19 positive cancer patients compared to negative cancer patients.