Preparation, Characterization and Cytotoxic Studies of Cisplatin-containing Nanoliposomes on Breast Cancer Cell Lines

Authors

  • Fateme Mohammadinezhad Department of Health Science, University of Eastern Piedmont, Novara, Italy.
  • Armin Talebi Department of Biochemical Engineering, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
  • Mohammadreza Allahyartorkaman Department of life science, National Taiwan University, Taipei, Taiwan.
  • Reza Nahavandi Department of Biochemical and Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 11155-4563, Iran.
  • Maryam Vesal Department of Biophysics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
  • Azim Akbarzadeh Khiyavi Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran.
  • Zeinab Jabbari Velisdeh Department of Chemical Engineering, Babol Noshirvani University of Technology, Babol, Iran.
  • Elham Saberian 8MDDr., PhD and Specialty Student, Pavol Jozef Šafárik University, Klinika and Akadémia Košice Bacikova, Kosice, Slovakia.
  • Paniz Mirmoghaddam Islamic Azad University of Medical Science, Mashhad, Iran.
  • Somayeh Eslami Mahan Research Centre, Mahan Pain Clinic, Tehran, Iran.
  • Parizad Ghanbarikondor Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran.
  • Armin Sedighi Department of Electrical Engineering, Islamic Azad University, Science and Research Branch, Qazvin, Iran.
  • Ali Habiba School of Mechanical Engineering, College of engineering, University of Tehran, North Kargar Street, Tehran, Iran.

Keywords:

breast cancer, cisplatin, nanoliposome

Abstract

Objective: Today, cancer is one the most important challenges in modern medicine. Breast carcinoma is one type of cancer that is treated with cisplatin, a chemotherapy drug. By using liposomal nanocarriers, this study seeks to increase the therapeutic efficiency of cisplatin.
Method: The zeta potential, particle size, and drug-release characteristics of nanoliposomal cisplatin were evaluated after it had been synthesized using the reverse phase evaporation technique. The cytotoxicity rate of nanoliposomal cisplatin was then assessed using the T-47D breast cancer cell line.
Results: This study’s liposomal nanoparticles (NPs) had a zeta potential of -24.9 mV and a particle size of 342.3 nm. 3.51% and 79.6%, respectively, were found to be the drug loading level and amount of encapsulated drug. A significant improvement over the free drug was seen in this nanoliposome’s cytotoxic effect on the T-47D breast cancer cell line (P<0.05).
Conclusion: According to what we have discovered, cisplatin liposomal nanocarriers may prove to be a cutting-edge chemotherapy treatment for breast cancer.

Downloads

Published

2023-07-30

Issue

Vol. 8 No. 2 (2023)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).