A Case of Dynamic Molecular Profile in Metastatic Lung Adenocarcinoma and the Significance of Multiple-site Testing

Authors

  • Radha Paturu Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Raghavendra Lingaiah Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Shalini Singh Department of Radiotherapy, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Niraj Kumari Department of Pathology and Lab Medicine, AIIMS Raebareli, Raebareli, Uttar Pradesh, India.
  • Narendra Krishnani Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Keywords:

Non-small cell lung cancer, molecular testing, intratumoral heterogeneity, ALK, targeted therapy

Abstract

Lung adenocarcinomas show intratumoral heterogeneity which has significant impact on the selection of targeted therapy. Multiple molecular sub-clones coexist within an individual tumour which determine recurrence and metastasis formation which is often under-evaluated in a single-site needle biopsy. Our case report demonstrates this intriguing phenomenon and the importance of multiple-site molecular testing to determine the dominant molecular alteration, and initiating the appropriate targeted therapy for better prognosis. Molecular testing from accessible metastatic sites in lung cancer is recommended for a complete assessment of prognosis and therapeutic options in recurrent and metastatic disease.

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Published

2024-04-22

Issue

Vol. 9 No. 2 (2024)

Section

Case Report

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).