Studying the Characteristics of Curcumin-Loaded Liposomal Nanoparticles

Authors

  • Iman Afyouni Department of Industrial Engineering, University of Houston, Texas, US. Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Isfahan, Iran.
  • Parizad Ghanbarikondori Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran.
  • Niki Sadeghi Pour Jam General Hospital Tehran, Iran.
  • Paria Mir Hashemian Department of Chemical Engineering, Sharif University of Technology, Iran.
  • Fereshtehsadat Jalali Department of Obstetrics and Gynecology, Faculty of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Armin Sedighi Department of Electrical Engineering, Islamic Azad University, Science and Research Branch, Qazvin, Iran.
  • Mohammadreza Allahyartorkaman Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.

Keywords:

Keywords: Curcumin, Liposome Nanoparticles, Thin-film hydration technique, Antioxidant

Abstract

Background: In this study, the physical and chemical properties of curcumin are extensively examined when it is incorporated into liposome nanoparticles, to enhance its therapeutic potency and bioavailability. Curcumin, a plant-derived polyphenol, has garnered attention for its anti-inflammatory, antioxidant, and anti-cancer activities. However, its clinical utility is hindered by several limitations, including poor water solubility, inadequate absorption, and rapid metabolism. By leveraging the potential of liposome nanoparticles to improve drug delivery and efficacy, this research aims to overcome these obstacles and unlock the full therapeutic potential of curcumin.

Methods: Curcumin-loaded liposome nanoparticles (CLLNs) were fabricated employing a thin-film hydration method, after sonication. The physicochemical attributes of CLLNs were subsequently characterized, encompassing particle size and zeta potential assessment utilizing dynamic light scattering (DLS), encapsulation efficiency (EE%) and drug loading efficiency (DLE%) determination through high-performance liquid chromatography (HPLC), investigation of in vitro drug release patterns in simulated biological fluids.

Results: The CLLNs optimized in this study had a mean particle diameter of less than 250 nm and a negative surface charge, implying good stability and potential for cellular uptake. The encapsulation efficiency and drug loading efficiency were both found to be high, indicating that curcumin was effectively loaded into the liposomes. In vitro release testing showed a sustained release pattern of curcumin from the CLLNs.

Conclusion: The research offered important observations about the advantageous physicochemical features of curcumin-loaded liposome nanoparticles, highlighting their potential as a cutting-edge delivery system for curcumin. The study demonstrated that CLLNs have high encapsulation and drug loading efficiencies, as well as controlled release and improved stability, which suggests their ability to enhance the therapeutic benefits of curcumin. These findings set the stage for future in vivo and clinical trials to fully investigate the potential of CLLNs in medical applications.

Downloads

Published

2024-05-29

Issue

Vol. 9 No. 2 (2024)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).