Hypoxia in Tumor Angiogenesis: An Update

Authors

  • Matthias Solomon Gamde Bingham University, Nigeria.
  • Ochanya Ogenyi Destiny Bingham University, Nigeria.
  • James O Adisa Bingham University, Nigeria.

Keywords:

Solid tumors-hypoxia-angiogenic factors

Abstract

Solid tumors, particularly breast cancer, undergo genetic and molecular changes that foster an immunosuppressive tumor microenvironment (TME), driven by angiogenic activation and metabolic shifts like elevated glycolysis. Angiogenesis, the formation of new blood vessels is essential for tumor survival, enabling oxygen and nutrient delivery as tumors exceed 1–2 mm³ in size. This commentary explores the mechanisms of angiogenesis in breast cancer, hypoxia’s role in driving these pathways, and emerging therapeutic strategies targeting these processes.

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Published

2025-06-08

Issue

Vol. 10 No. 2 (2025)

Section

Commentaries/ letter to editor

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).