Investigation of Characteristics and Behavior of Loaded Carboplatin on the, Liposomes Nanoparticles, on the Lung and Ovarian Cancer: An In-Vitro Evaluation

Authors

  • Majid Hasanzadegan Roudsari Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  • Nasim Saeidi Department of Medical Genetic, International Campos, Shahid Sadoughi University of Medical Science, Yazd, Iran.
  • Nahid Kabiri Gratuated from Veterinary Medicin, Shahid Chamran University of Ahvaz, Iran.
  • Afrooz Ahmadi Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch , Islamic Azad University, Tehran, Iran.
  • Maral Mazloumi Tabrizi Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch , Islamic Azad University, Tehran, Iran.
  • Hasan Ebrahimi Shahmabadi Department of Microbiology, Parasitology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
  • Azim Akbarzadeh Khiyavi Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
  • Behnaz Reghbati

Keywords:

Carboplatin- nano liposomes nanoparticle- lung and ovarian cancer

Abstract

Carboplatin is a chemotherapy drug which is used against some forms of cancer such as ovarian and lung carcinoma. This research was investigated to optimize and assess the Cytotoxicity of carboplatin Nanoliposomes on ovarian and lung cancer cell lines. Nanoparticles were prepared using reverse phase evaporation technique and characterized for light microscopy, spectrophotometry and drug-release properties. In the next step, A2780S and A2780CP (ovarian) and TC1 (lung) cell lines were used to determine the rate of Nano liposomal carboplatin cytotoxicity. In this research, size and zeta potentials are 244.3±16.7nm and 22.9± 1.7 mV, respectively. High encapsulation capacity (78.6±3.7%) confirmed the efficiency of the reverse phase evaporation technique. The cytotoxic effect of this Nano liposome on all cell lines was significantly increased when compared with the free drug (P<0.05). Our findings suggest that carboplatin liposomal Nanocarriers could serve as alternative chemotherapy modality for ovarian and lung cancer therapy.

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Published

2016-04-25

Issue

Vol. 1 No. 1 (2016)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).