Association between LGR5 Expression and Overall Survival in Patients with Colorectal Cancer: A Retrospective Study from Indonesia

Authors

  • Edward Julio Suhendra Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
  • Warsinggih Warsinggih Division of Digestive, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Hasanuddin University Hospital, Makassar, Indonesia. https://orcid.org/0000-0002-1756-9039
  • Muhammad Ihwan Kusuma Division of Digestive, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia.
  • Mappincara Mappincara 2Division of Digestive, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
  • Prihantono Prihantono Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Hasanuddin University Hospital, Makassar, Indonesia. https://orcid.org/0000-0002-8247-0457
  • Joko Hendarto Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Department of Public Health Sciences, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
  • Rina Masadah 4 Hasanuddin University Hospital, Makassar, Indonesia; 6 Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia https://orcid.org/0000-0002-1380-4759
  • Muhammad Faruk Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Hasanuddin University Hospital, Makassar, Indonesia

Keywords:

colorectal cancer, Lgr5 protein, overall survival

Abstract

Background: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), also known as GPR49, is a Wnt signaling target that plays an important role in colorectal carcinogenesis and is often associated with poor prognosis in patients with colorectal cancer. Aim of this study was to assess the influence of LGR5 expression and its relationship with overall survival (OS) in colorectal cancer.

Material and methods: This retrospective study assessed LGR5 expression via immunohistochemistry (IHC) in 30 archival colorectal cancer tissue samples from patients resected between 2019-2020 in Makassar, Indonesia. The association between LGR5 expression levels (high vs. low) and overall survival (OS) was analyzed.

Result: Research results were obtained from 30 samples. Overall, 8 patients with high LGR5 expression and 22 patients with low LGR5 were reported. Among the total number of patients enrolled, 22 patients had an OS of 3 years and 8 patients had an OS of 5 years. Statistical analysis showed that there was no association between LGR5 expression and the clinical profile of colorectal cancer patients (p-value > 0.05). A statistically significant association between OS and both tumor stage and histopathological grading (p-value <0.001 and 0.016, respectively) was found. However, no statistically significant association between OS and LGR5 expression was observed (p-value 0.418).

Conclusion: LGR5 expression was not associate with either OS and or clinical characteristics of CRC patients in Makassar, Indonesia. However, there was a tendency for low LGR5 expression to be associated with improved OS, although this finding was not statistically significant. Both tumor stage and histopathological grading were associated with OS.

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Published

2025-10-26

Issue

Vol. 10 No. 4 (2025)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).