Meta-analysis of Studies Investigating Association between FTO Gene Polymorphisms and Breast Cancer

Authors

  • Maryam Gholamalizadeh Cancer resaerch Center, Shaheed Beheshti University of Medical Sciences, Tehran Iran.
  • Saeid Doaei School of Public Health, Gilan University of Medical Sciences, Rasht, Iran
  • Ali Sanjari Moghadam 1) Dept. of Social Medicine, Medical School, Shaheed Beheshti University of Medical Sciences, Tehran Iran
  • Abolfazel Movafagh Dept. of Genetics, Medical School, Shaheed Beheshti University of Medical Sciences, Tehran Iran
  • Seyedeh Zahra Mousavi Jarrahi School of Allied Medical Sciences, Shahroud university of Medical Science
  • Alireza Mosavi Jarrahi Dept. of Social Medicine, Medical School, Shaheed Beheshti University of Medical Sciences, Tehran Iran

Keywords:

FTO Gene Polymorphisms, Breast Cancer, Meta-analysis, rs1477196 and rs9939609 polymorphism

Abstract

Back Objectives: The aim of this study is to pool the result of studies on the association between FTO gene polymorphisms and breast cancer (BC).
Material and Methods: We searched PubMed, Embase, Science Direct, Scopus, web of science, and Cochran to identify studies investigating the associations between the rs1477196 and rs9939609 polymorphisms and BC risk. We pooled adjusted odds ratios (ORs) as overall. ORs were estimated using a random effects model.
Results: In total, 16 articles were included in the final analysis. Considering the dominant model of inheritance, there was an inverse association between the rs1477196 polymorphism and BC (OR 0.76 [0.64- 0.91]). There was not observable heterogeneity (I2: 0.0%, P=.867), but with a small study effect (b=1.19, P=.03) in this analysis. Moreover, there was not any association between the rs9939609 polymorphism and BC (OR 0.98 [0.79- 1.2]). There was not observable heterogeneity (I2: 23.1%, P=.27) and small study effect (b=-3.817, P=.303) in this analysis.
Conclusions: The carriers of rs1477196 polymorphism of FTO are at lower risk for BC. Carriers of Rs9939609 polymorphism had no association with Breast cancer risk.

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Published

2019-12-15

Issue

Vol. 4 No. 4 (2019)

Section

Systematic Review and Meta-analysis:

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).