Prostate Cancer: Germline Mutations in BRCA1 and BRCA2

Authors

  • Pankaja Umarane Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-Univeristy), JNMC Campus, Belagavi-10, Karnataka, India.
  • Shridhar C Ghagane Department of Biotechnology, KAHER‟s Dr. Prabhakar Kore Basic Science Research Center, 3rd Floor, V. K. Institute of Dental Sciences Campus, Nehru Nagar, Belagavi, Karnataka, India
  • Rajendra Nerli Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-Univeristy), JNMC Campus, Belagavi-10, Karnataka, India.

Keywords:

Prostate cancer, Mutations, BRCA1 and BRCA2.

Abstract

Genetic alterations are one of the important known risk factors of Prostate cancer. The family predisposition of breast and ovarian cancers may cause the lethal progression of familial prostate cancer in some men. The Association of germline mutations in BRCA1 and BRCA2 genes can cause breast cancer in almost 35% of women and 9% of men. Carriers of these pathogenic variants have a higher risk of causing prostate cancer. This study focused on the analysis of mutations causing prostate cancer around the world, associated with breast cancer susceptibility genes.

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Published

2023-03-16

Issue

Vol. 8 No. 1 (2023)

Section

Systematic Review and Meta-analysis:

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).