Do Thymomas with and without Myasthenia Gravis Share Differences in Clinicopathological Features?

Kahkashan Riaz; Pallavi Prasad; Ritu Verma; Shubhi Kamthan

doi:10.31557/apjec.1393.20250927

Authors

Kahkashan Riaz Department of Pathology, Autonomous State Medical College, Gonda, India.
Pallavi Prasad Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Ritu Verma Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Shubhi Kamthan Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

DOI:

https://doi.org/10.31557/apjec.1393.20250927

Keywords:

Thymomas, myasthenia gravis, anti-anticholinesterase receptor antibody, clinicopathological characteristics, Masoka staging

Abstract

Objective: Analyses of prognostic effects of age, sex, pathological stage, histological finding and Masoka staging between thymomas with and without myasthenia gravis are to be made in this study.

Method: This retrospective study comprise of 38 patients who underwent either surgery or biopsy for histological confirmation of thymoma and the specimens were received in the department of pathology. Twenty-nine cases presented with symptoms of myasthenia gravis and nine cases presented without symptoms of myasthenia gravis.

Result: We hereby describe a group of thymoma patients treated at a tertiary cancer centre in northern India and compare the clinicopathological characteristics between the subset of patients of thymoma having MG and those without MG.

Conclusion: Due to a low number of cases of the two group, no significant correlation could be made. Patients diagnosed as thymoma without myasthenia gravis only showed a significant correlation between age and sex (r=0.845, p=0.004).