Prostate Cancer Incidence and Mortality Linked to Metalworking Fluid Exposure: A Systematic Review and Meta-Analysis

Zahra Moradpour; Amin Barik; Goljamal Jorjani; Mohammad Reza Taherian; Sepideh Tousizadeh; Aram Halimi; Yaser Soleimani; Mobina Karimian; Tina Khavari; Fateme Azizi Kalankari; Fatemeh Asadipour; Mojtaba Azari; Niloofar Yousefzadeh Shakouri; Saeideh Karamian; Nasser Bahari; Alireza Mosavi Jarrahi

doi:10.31557/apjec.2024.7.1.159-161

Authors

Zahra Moradpour Department of Occupational Health Engineering and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Amin Barik Department of Health, Safety and Environment, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Goljamal Jorjani Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Reza Taherian Student Research Committee, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sepideh Tousizadeh Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Aram Halimi Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Yaser Soleimani Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mobina Karimian Department of Occupational Health Engineering, Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Tina Khavari Department of Occupational Health Engineering and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fateme Azizi Kalankari Department of Occupational Health Engineering and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh Asadipour Department of Occupational Health Engineering and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mojtaba Azari Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Niloofar Yousefzadeh Shakouri Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeideh Karamian Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nasser Bahari Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza Mosavi Jarrahi Department of Social Medicine, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

DOI:

https://doi.org/10.31557/apjec.2024.7.1.159-161

Abstract

Introduction: Prostate cancer is a significant health concern, and occupational exposures, including metalworking fluid (MWF) exposure, have been implicated as potential risk factors. This protocol outlines a systematic review and meta-analysis methodology to investigate the association between MWF exposure and prostate cancer risk among male workers.

Methods: Eligible studies include cohort, case-control, and cross-sectional studies published until between 1990 and 2023 focusing on MWF exposure and prostate cancer risk in male workers. Two independent reviewers will screen studies, extract data using a standardized form, conduct a meta-analysis using random-effects models, and assess study quality using the Newcastle-Ottawa Scale. Heterogeneity will be assessed, and sensitivity analyses will be conducted to explore sources of bias.

Results: Anticipated outcomes include a comprehensive list of eligible studies, a synthesized analysis using random-effects meta-analysis models to estimate the association between MWF exposure and prostate cancer risk, and a quality assessment report of included studies. Subgroup analyses based on MWF type, exposure duration, and study design will be performed to explore heterogeneity.

Conclusion: This systematic review and meta-analysis protocol aim to provide robust evidence on the association between MWF exposure and prostate cancer risk among male workers. The anticipated findings will have implications for occupational health practices and may guide future research and intervention strategies.