Manikya Bhasma as Nanomedicine for Cancer Cells Treatment  and its Characterization Using Modern Scientific Tools

Reena .; Preeti Sharma; Nakuleshwar Dut Jasuja; Sunil Kumar

doi:10.31557/apjec.2024.7.1.47-55

Authors

Reena . Research Scholar, School of Basic and Applied Sciences, Nirwan University Jaipur, India.
Preeti Sharma Dean and Professor, School of Basic and Applied Science, Nirwan University Jaipur, India.
Nakuleshwar Dut Jasuja Professor and Additional Registrar Vivekananda Global University, Jaipur (Rajasthan), India.
Sunil Kumar University Department of Electronic Sciences, Babasaheb Bhimrao Ambedkar Bihar University, Muzaffarpur, India.

DOI:

https://doi.org/10.31557/apjec.2024.7.1.47-55

Keywords:

Manikya Bhasma, Nanomedicine, lung cancer cells (A-547), breast cancer cells (MCF-7)

Abstract

Objective: This study is focused on evaluating the safety and effectiveness of Manikya Bhasma, an Ayurvedic preparation, as a nanomedicine for cancer treatment, and exploring its potential therapeutic properties using modern scientific tools.

Methods: Manikya Bhasma, composed of purified ruby, orpiment, and arsenic sulfide, was analyzed using XRD (X-ray Diffraction) for crystallite size determination, FESEM (Field Emission Scanning Electron Microscopy) for morphological analysis, EDS (Energy Dispersive X-ray spectroscopy) for elemental composition, and FTIR (Fourier Transform Infrared Spectroscopy) for functional group identification. The anticancer activity of Manikya Bhasma nanoparticles was assessed against breast cancer (MCF-7) and lung cancer (A-547) cell lines at varying concentrations (0-1000 µg/mL).

Results: The XRD analysis revealed an average crystallite size of 60 nm. FESEM micrographs confirmed the uniform distribution of particles within the sample. Notably, Manikya Bhasma demonstrated a clear dose-dependent anticancer activity against both MCF-7 and A-547 cell lines, providing reassurance about its potential effectiveness.

Conclusion: This study suggests that Manikya Bhasma has the potential to be a promising nanomedicine for cancer treatment, highlighting the therapeutic relevance of traditional Ayurvedic medicine in modern scientific research. This research serves as a bridge between traditional and modern approaches, offering new insights into the application of Ayurvedic formulations in contemporary medicine.