Review Article: Chlorothalonil and Cancer: A Comprehensive Overview

Authors

  • Yaser Soleimani Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammad Javad Shahsavari Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Parniyan Sadeghi Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Hamid Sadeghi Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Ali Aryanejad Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Zeynab Qashami Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Alireza Khazali Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Narges Noori Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Saeideh Karamian Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammad Nayebi Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Amirhossein Jadidi Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mahdi Esfandiari Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Matin Tavassol Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mobina Mohammadi Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Ayda Khedri Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Alireza Mosavi Jarrahi Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

DOI:

https://doi.org/10.31557/apjec.1783.20250316

Abstract

Chlorothalonil, a broad-spectrum fungicide, has been extensively used in agriculture for over five decades. It plays a vital role in preventing fungal diseases in various crops, contributing significantly to increased agricultural productivity. However, concerns about the safety of chlorothalonil have arisen, particularly regarding its potential to cause cancer. The International Agency for Research on Cancer (IARC) classified chlorothalonil as a possible human carcinogen (Group 2B), which has led to intensified scrutiny of its long-term effects on human health. This review aims to critically evaluate the existing body of evidence on chlorothalonil’s potential carcinogenicity, examining toxicological data, mechanisms of action, and epidemiological studies, while also discussing regulatory actions and future research directions.

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Published

2025-03-16

How to Cite

Soleimani, Y., Shahsavari, M. J., Sadeghi, P., Sadeghi, H., Aryanejad, A., Qashami, Z., … Mosavi Jarrahi, A. (2025). Review Article: Chlorothalonil and Cancer: A Comprehensive Overview. Asian Pacific Journal of Environment and Cancer, 20250316. https://doi.org/10.31557/apjec.1783.20250316

Issue

Asian Pacific Journal of Environment and Cancer

Section

Review and Meta-analysis