The Association between PM2.5 Exposure and Hippocampal Volume: A Systematic Review

Elizabeth Feloni Lukito; Kevin Tandarto; Maureen Miracle Stella; Ignatius Ivan; Harvey Sudharta; Gilbert Golahi; Kenny Wijaya Sutanto; Yuda Turana; Bryany Titi Santi; Yanto Budiman; Yopi Simargi

doi:10.31557/apjec.2022.5.1.11-16

Authors

Elizabeth Feloni Lukito School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Kevin Tandarto School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. https://orcid.org/0000-0002-6998-8091
Maureen Miracle Stella School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. https://orcid.org/0000-0003-2932-3498
Ignatius Ivan School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. https://orcid.org/0000-0001-6177-3793
Harvey Sudharta School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Gilbert Golahi School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Kenny Wijaya Sutanto School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Yuda Turana Clinical Neurologist, Department of Neurology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. https://orcid.org/0000-0003-4527-0285
Bryany Titi Santi Clinical Epidemiologist, Department of Public Health Science, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. https://orcid.org/0000-0002-6418-3235
Yanto Budiman Clinical Radiologist, Department of Radiology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. https://orcid.org/0000-0002-2767-1408
Yopi Simargi Clinical Radiologist, Department of Radiology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. https://orcid.org/0000-0002-5958-2389

DOI:

https://doi.org/10.31557/apjec.2022.5.1.11-16

Keywords:

pollution exposure, PM2.5 exposure, hippocampal volume, magnetic resonance imaging

Abstract

Background: Existing air quality is decreasing, as evidenced by the increase in air pollution. Air pollution does not only affect the respiratory system, but also affecting the nervous system, and furthermore causing impaired cognitive function that can be predicted through the image of the hippocampus.
Objective: This study wanted to determine the significance of the relationship between PM2.5 (Particulate Matter) pollutant exposure and hippocampal volume in adults.
Method: This research is a PRISMA 2020 based systematic study using Google Scholar, PubMed, and Proquest as databases. Research inclusion criteria were studies with subjects over 19 years old, using MRI techniques, published in English, having sufficient data for extraction.
Result: There are 5 studies from 2015 to 2020 which stated that there was no statistically significant relationship between PM2.5 pollutant exposure and hippocampal volume (n = 5) (P-value > 0.05, 0.71, 0.8, 0.32), and the study obtained significant results (n = 1) (P-value < 0.005). Discussion: Although the results of the study did not prove a significant difference in hippocampal volume, several recent theories regarding hippocampal neurogenesis in adults are able to support these results.
Conclusion: From this study, it was not proven that there was a significant relationship between PM2.5 pollutant exposure and hippocampal volume.