Comparative Study of Concurrent Chemoradiotherapy vs Radiotherapy alone in Locally Advanced Head and Neck Cancer

Saroj Dhaka; Nishant Kamboj; Neeti Sharma; Rajesh Kumar Kumar; Kamlesh Kumar Harsh; Shankar Lal Jakhar

doi:10.31557/apjcc.2024.9.3.443-446

Authors

Saroj Dhaka Assistant Professor, Dr S N Medical College Jodhpur, India.
Nishant Kamboj Senior Resident, Atrctri, India.
Neeti Sharma Senior Resident, Atrctri, India.
Rajesh Kumar Kumar Senior Resident, Atrctri, India.
Kamlesh Kumar Harsh Senior Resident, Atrctri, India.
Shankar Lal Jakhar Senior Resident, Atrctri, India.

DOI:

https://doi.org/10.31557/apjcc.2024.9.3.443-446

Keywords:

Radiotherapy alone, Induction chemotherapy, Unresectable locally advanced head and neck cancer

Abstract

Purpose: The purpose of this study was to compare treatment response and toxicity profile among two groups of unresectable locally advanced head and neck malignancies receiving concurrent chemo-radiotherapy versus radiotherapy alone after completing neoadjuvant chemotherapy.

Material and methods: Total 50 patients received neoadjuvant chemotherapy (inj. paclitaxel 175 mg/m² D1, Cisplatin 80mg/m² divided in 2 days & inj 5FU 1gm/m² iv d1&d2). Then randomly allotted into above two groups to receive 66 Gy fractionated RT alone versus RT along with concurrent 3 weekly inj Cisplatin 80mg/m² divided in two days. Disease response was evaluated by RECIEST criteria.

Result: All patients tolerated treatment well, no major adverse effects were monitored in two groups. There was no significant statistical difference in treatment response, which was found 88% vs 80% in concurrent CTRT vs RT alone. However toxicity profile was higher in concurrent CTRT group. The 6 months PFS were 83.3% and 78.3% in CTRT and RT alone groups respectively; (X2 =0.196, p value= >.05).