Primary Squamous Cell Carcinoma of Thyroid – A Case Report  with Emphasis on Treatment Options and Review of Literature

Gautam Vedagiri Vydia; Ramanaiah K; Aravind Krishnamoorthy; Sadanand S

doi:10.31557/apjcc.2025.10.1.369-371

Authors

Gautam Vedagiri Vydia Department of Radiation Oncology, Cancer Institute (WIA), Adyar, India.
Ramanaiah K Department of Radiation Oncology, Cancer Institute (WIA), Adyar, India.
Aravind Krishnamoorthy Department of Surgical Oncology, Cancer Institute (WIA), Adyar, India.
Sadanand S Department of Radiation Oncology, Cancer Institute (WIA), Adyar, India.

DOI:

https://doi.org/10.31557/apjcc.2025.10.1.369-371

Keywords:

Primary squamous cell carcinoma of thyroid, review of literature, adjuvant radiotherapy, Lenvatinib

Abstract

Introduction: Primary squamous cell carcinoma of thyroid (PSCCT) is a rare entity with less than 100 cases reported in literature. It constitutes about 1% of all thyroid cancers. It has an aggressive behaviour and unfavourable prognosis. We report a rare case of PSCCT and provide a review of literature on PSCCT.

Case Report: A 45 year old gentleman with hypertension as co morbid condition reported to our hospital with complaints of swelling in anterior part of the neck. He was diagnosed as a case of carcinoma of thyroid. He underwent Total Thyroidectomy under general anaesthesia. With histopathology and IHC correlation, diagnosed as PSCCT. He received adjuvant RT to tumor bed to a total dose of 60 Gray (Gy) over a period of 6 weeks.

Conclusion: PSCCT is a very rare disease with very aggressive course. There is no consensus on the line of management. Lenvatinib can be tried in PSCCT as it resembles ATC.