Immune Thrombocytopenia as the Initial Presentation of  Metastatic High-Grade Serous Ovarian Cancer: A Case Report

Ali Mohammad Esfandiary Rad; Seyed Alireza Javadinia; Alireza Noferesti

doi:10.31557/apjcc.2026.11.1.121-124

Authors

Ali Mohammad Esfandiary Rad Student Research Committee, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Seyed Alireza Javadinia Assistant Professor, Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Alireza Noferesti Department of Internal Medicine, Faculty of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran.

DOI:

https://doi.org/10.31557/apjcc.2026.11.1.121-124

Keywords:

immune thrombocytopenia, paraneoplastic syndrome, ovarian carcinoma, high-grade serous ovarian carcinoma

Abstract

Introduction: Immune thrombocytopenia (ITP) is an immune-mediated multifactorial disorder characterized by isolated thrombocytopenia which is divided in primary (without an underlying known cause) and secondary (that an underlying cause can be detected). Secondary ITP can be a type of paraneoplastic syndromes (PNS) that occurs in setting of a malignancy.

Case Presentation: Here, we describe a 63-year-old female with newly diagnosed ITP and chief complaint of lower limb ecchymosis which further workups revealed a metastatic highgrade papillary serous ovarian carcinoma (HGSOC) and also after treatment, clinical and laboratory parameters (CA-125) indicated a successful therapeutic response.

Conclusion: This case highlights the importance of evaluating secondary causes, including underlying malignancies, in patients with newly diagnosed ITP, particularly in older individuals. Recognition of ITP as a potential paraneoplastic manifestation may facilitate earlier cancer detection and appropriate management, ultimately improving clinical outcomes.