The Correlation of Radiogenomics and Green Tea Extract  Polyphenols: Redefining Head and Neck Cancer Management

Manish Tenguria; Nikita Bahuguna; Nikhil Garg; Deependra Pratap Singh; Payal Gupta; Meenu Gupta; Nishant Rai

doi:10.31557/apjcc.2025.10.4.1207-1219

Authors

Manish Tenguria Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun-248002, Uttarakhand, India. https://orcid.org/0009-0002-6730-8897
Nikita Bahuguna Department of Microbiology, Graphic Era (Deemed to be University), Dehradun-248002, Uttarakhand, India. https://orcid.org/0000-0002-6885-0111
Nikhil Garg Department of Civil Engineering, Graphic Era (Deemed to be University), Dehradun-248002, Uttarakhand, India. https://orcid.org/0000-0001-9126-5896
Deependra Pratap Singh Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun-248002, Uttarakhand, India. https://orcid.org/0000-0002-8897-7777
Payal Gupta Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun-248002, Uttarakhand, India. https://orcid.org/0000-0001-8556-1752
Meenu Gupta Department of Oncology, Velmed Hospital, Dehradun, Uttarakhand, India.
Nishant Rai Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun-248002, Uttarakhand, India.

DOI:

https://doi.org/10.31557/apjcc.2025.10.4.1207-1219

Keywords:

Anticancer activity, Catechins, Epigallocatechin gallate (EGCG), Green tea, Head and Neck Cancer (HNC), Radiogenomics

Abstract

Radiogenomics, an emerging paradigm that combines genomic and imaging information, is poised to advance precision oncology, particularly in head and neck cancer (HNC). This review explores the potential integration of radiogenomics with the polyphenol epigallocatechin-3-gallate (EGCG) from green tea, building on systematic and bibliometric analyses of an unprecedented amount of information (molecular and clinical milestones and advances) related to oncology and radiogenomics, spanning from 1997 to 2024. Including an antioxidant and anticancer compound, EGCG has shown promise in modifying the response to radiation and modifies certain biologic pathways. It is proposed that radiogenomic markers will be effective in modifying toxicity, potentially augmenting precision treatments in HNC, while simultaneously integrating the fields of genetics, imaging, and nutraceuticals into one new area for future research and clinical practice.