Quality of Life in Iranian Breast Cancer Patients Undergoing  Chemotherapy: A Cross-Sectional Study from Qazvin

Mahfam Alijaniha; Mahdi Mirzaalimohammadi; Mahdin Alijaniha

doi:10.31557/apjcc.2025.10.4.1177-1182

Authors

Mahfam Alijaniha Pharm.D, Department of Pharmaceutical, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
Mahdi Mirzaalimohammadi Ms.C of Civil Engineering, Department of Soil and Foundation, Faculty of Engineering, Semnan University, Semnan, Iran.
Mahdin Alijaniha Pharm.D, Department of Pharmaceutical, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI:

https://doi.org/10.31557/apjcc.2025.10.4.1177-1182

Keywords:

Breast cancer, quality of life, chemotherapy, emotional functioning, side effects

Abstract

Background and Aims: Breast cancer is a leading health concern among Iranian women. This study evaluated the quality of life (QoL) in breast cancer patients undergoing chemotherapy at a specialized cancer center in Qazvin, Iran.

Materials and Methods: This cross-sectional study included 50 women aged ≥18 years with breast cancer receiving chemotherapy from the second cycle onward. Participants completed validated Persian versions of EORTC QLQ-C30 and QLQ-BR23 questionnaires. Cognitive function was assessed using a standardized cognitive assessment battery.

Results: Emotional functioning was the most severely affected QoL domain. Cognitive impairments were observed in working memory (25.3), reaction time (21.1), and organizational skills (22.1). Prevalent symptoms included insomnia (13.5), fatigue (12.4), and appetite loss (11.6). Significant negative correlations were found between psychological symptoms and overall QoL (p<0.05).

Conclusion: Chemotherapy significantly impacts multiple QoL dimensions in Iranian breast cancer patients. Integrated interventions addressing cognitive rehabilitation and psychological support are essential components of comprehensive cancer care.