Improved Antitumor Efficacy of Liposome-Encapsulated Selenium Nanoparticles

Authors

  • Mahya Asadalizadeh Department of Biomedical Engineering, College of Engineering, University of Illinois at Chicago, Chicago, IL, USA.
  • Hamid Ghahremani Radio_ oncology Department Science Valiasr Hospital Zanjan University Medical Science, Zanjan, Iran.
  • Parizad Ghanbarikondori Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran.
  • Helia Asadalizadeh Department of Biology, Harold Washington College, City College of Chicago, Chicago, IL, USA.
  • Parham Rahmani Faculty of pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Rostamian Motlagh Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.

Keywords:

Anticancer activity, Oral cancer therapy, Liposomes

Abstract

Overview: This investigation chronicles the phytogenic synthesis of selenium nanoparticles (SeNPs) and their subsequent entrapment within phospholipid liposomes to construct a precision nanovector for oral-squamouscell-carcinoma therapy.

Methods: The plant-derived SeNPs were loaded into liposomes via a thin-film hydration approach. Dynamic light scattering (DLS) assessed their hydrodynamic diameter and zeta potential.

Results: This nanoparticle was then sequestered via a thin-film-hydration protocol that yielded liposomes with a mean hydrodynamic diameter of 235 nm, a polydispersity index of 0.15. Dynamic-release profiling in phosphate-buffered saline (pH 7.4, 37 °C) revealed a sustained discharge of 35 % of the payload over 62 h dramatically slower than the 95 % burst exhibited by free SeNPs attesting to the kinetic moderation conferred by the bilayer matrix. Functionally, MTT assays on an oral-cancer cell line demonstrated a 72 % reduction in viability after 24 h, significantly eclipsing the 38 % inhibition achieved by unencapsulated nanoparticles (p < 0.001).

Conclusion: These data indicate that liposomal sequestration furnishes SeNPs with enhanced colloidal stability, protracted release dynamics, and markedly elevated in-vitro antineoplastic potency, thereby positioning the platform as a compelling, biocompatible candidate for targeted oral-cancer therapeutics and warranting subsequent in-vivo validation.

Downloads

Published

2025-06-08

Issue

Vol. 10 No. 2 (2025)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).