Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii

Authors

  • Anusha Anish PK Das Institute of Medical Sciences, Palakkad, India.
  • Sherena Padinjarevattom Abdulkadir Department of Biochemistry, Little Flower Medical Research Centre, Angamaly, India.
  • Annamala Panthapulakkil Theru Department of Biochemistry, Jubilee Mission Medical College, Thrissur, India.
  • Mukkadan Joseph Kurian Research Director, Little Flower Medical Research Centre, Angamaly, India

Keywords:

Oxy-carotenoids, Coriandrum sativum, Murraya koenigi, anti-mutagenic activity, Ames test

Abstract

Introduction: Edible and medicinal plants contain active principles that can act as antimutagens, and hence their intake may be useful for human cancer prevention. Green leafy vegetables are important sources of carotenoids which possess antioxidant, anti-inflammatory and antimutagenic properties.
Objective: To study the antimutagenic activity of oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves).
Methods: Oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) were investigated for antimutagenic activity in vitro by Ames test using Salmonella typhimurium strains TA 98 and TA 1535. Mutagens used were, nitro-o- phenylenediamine (NPD) (20μg/plate) and N-methyl- N-nitro-N-nitrosoguanidine (MNNG) (1μg/ plate).
Results: The results revealed that oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) administered at doses of 1.0 mg, 2.5 mg and 5 mg per plate significantly inhibited mutagenicity induced by NPD and MNNG.
Conclusion: These findings suggest that oxycarotenoid- rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) have antimutagenic properties.

Downloads

Published

2020-12-07

Issue

Vol. 5 No. 4 (2020)

Section

Research Articles/ Original Work

License

 West Asia Organization for Cabcer Prevention retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4 (This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited).